Newborn screening for genetic predisposition of type 1 diabetes using a polygenic 51 SNP risk score.
AVAnT1A
Primary prevention study to determine wether vaccinating children with an elevated genetic risk for type 1 diabetes against SARS-CoV influences immune development, beta-cell function, and the risk of islet autoimmunity.
SINT1A
Primary intervention study to determine whether daily administration of B. infantis EVC001 until age 12 months to children with elevated genetic risk for type 1 diabetes reduces the cumulative incidence of beta-cell autoantibodies in childhood.
POInT
Primary intervention study to determine wether daily administration of oral insulin to children with elevated genetic risk for type 1 diabetes reduces the cumulative incidence of beta-cell autoantibodies and diabetes in childhood.
